beaucell :: regenerative beauty therapy


		Decline in stem cell production with age As we age, however, the bone marrow releases fewer stem cells, giving us less power to repair the damage of ageing. Treatment with adult stem cells reverses this process. In healthy individuals, skin youthfulness is maintained by epidermal stem cells which self-renew and generate daughter cells that become new skin. Despite accumulation of aging blemishes and changes in aged skin, epidermal stem cells are maintained at normal levels throughout life. Therefore, skin ageing is caused by impaired stem cell mobilisation from the bone marrow or reduced number of stem cells able to respond to repair signals.⁶ This means that, if we increase the number of circulating stem cells, by mobilising from the bone marrow, and by infusion of new umbilical cord cells we should dramatically change this cell behaviour. It has been postulated that stem cell exhaustion from the bone marrow is partly responsible for the process of cardiovascular ageing and the resulting diseases such as angina, heart attack, stroke and senile dementia. It has now been proven that stem cell damage in the bone marrow, from aging, is responsible for coronary artery disease and resultant cardiac muscle damage.^{1, 2, 4} This means that cardiac disease can be prevented by stem cell therapy. As aging progresses, there is a decline in the brain's capacity to produce new neurons. The underlying cause of the declining neurogenesis is unknown, but is presumably related to age-related changes that occur during normal aging of the brain. It is exacerbated by age-related neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.⁵ References: 1. Spyridopoulos I et al. Arteriosclerosis, Thrombosis & Vascular Biology. 28(5):968-974, May 2008. 2. José J. Fuster, Vicente Andrés.Circulation Research. 2006;99:1167.2006 American Heart Association, Inc.Reviews.Telomere Biology and Cardiovascular Disease. 3. Ignacio Flores, Roberta Benetti and Maria A Blasco. Telomerase regulation and stem cell behaviour. Current Opinion in Cell Biology 2006, 18:254–260. 4. Frederick M. Rauscher et al.Aging, Progenitor Cell Exhaustion, and Atherosclerosis. Circulation, The American Heart Association. 5. TL Limke, MS Rao, Neural stem cell therapy in the aging brain: pitfalls and possibilities. J Hematother Stem Cell Res (2003) 12: 615-23. 6. Zouboulis CC, Adjaye J, Akamatsu H, Moe-Behrens G, Niemann C.Human skin stem cells and the ageing process. Exp Gerontol. 2008 Sep 9.